The proteomic approach to research the pathogenesis, diagnostic, prognostic and new therapeutic targets in osteoarthritis

Comunicaciones a congreso

R&D expenditure in the EU: convergence or divergence?

This article examines the convergence of the R&D expenditure in the EU28 for 2004–2015. We initially run a sigma convergence analysis and the results show convergence in the total expenditure, due to the behaviour of the business and higher education sectors, despite government sector divergence. However, noticeable differences between the EU15 and 13 EU countries are apparent. The business enterprise sector is the main driver of EU15 R&D convergence, whereas for the EU13 this role is played by the government expenditure. In addition, the economic crisis has impacted differently on both groups. The club convergence approach allows us to explore these insights through individualized analysis and clusterization. Results for the EU28 show two clubs for the total expenditure, but the analysis of its components reveals a larger grouping. Our results evidence the necessity of revising the EU R&D policies towards greater coordination and resources, and the implementation of new instruments, due to the impact of this expenditure on growth, development and integration

Alternative Splicing in Endothelial Senescence: Role of the TGF-β Co-Receptor Endoglin

No abstract available

Bubble bursting jets are driven by the purely inertial collapse of gas cavities

The analysis of numerical simulations describing the collapse of capillary cavities reveals that the jets originated from the bursting of bubbles are driven by the condition that the dimensionless liquid flow rate per unit length directed towards the axis of symmetry, $q_\infty$, remains nearly constant in time. This observation, which is justified in physical terms because liquid inertia prevents appreciable changes in $q_\infty$ during the short time scale characterizing the jet ejection process, together with the fact that bubble bursting jets are produced from the bottom of a conical cavity, justify the purely inertial scalings for the jet width and velocity found here, $r_{jet}\propto\sqrt{q_\infty\tau}$ and $v_{jet}\propto \sqrt{q_\infty/\tau}$, with $\tau$ indicating the dimensionless time after the jet is ejected, a result which notably differs from the common belief that the jet width and velocity follow the inertio-capillary scaling $r_{jet}\propto \tau^{2/3}$ and $v_{jet}\propto \tau^{-1/3}$. Our description reproduces the time evolution of the jet width and velocity for over three decades in time, obtaining good agreement with numerical simulations from the instant of jet inception until the jet width is comparable to that of the initial bubble.Comment: 15 pages, 10 figures. Figures are revised and properly referenced (v100323

Cuatro enterramientos calcolíticos en hoyo del Cerro de la Cabeza (Ávila)

This paper presents a thorough description of four pit burials dated to the Copper Age and recovered during the rescueexcavation of a pit site. The lot consists of a multiple pit burial containing six individuals with clear proofs of violenceplus three other single pit burials. The inhumation was the funerary treatment followed in all cases and proofs of secondaryburial have been also documented. Data on material culture, physical anthropology, paleopathology, palaeodiet,archaeopalinology and radiocarbon dating of the human remains are included for each burial pit. The paper proposesan overall archaeological interpretation of these funerary testimonies in their cultural context. Their probable extraordinarycharacter is highlighted, as relegated burial cases at the margins of the everyday normative mortuary rules.En este trabajo se describen en detalle las cuatro fosas funerarias de época calcolítica descubiertas en un campo dehoyos objeto de una excavación de urgencia. Se trata de una fosa múltiple con seis individuos con claras pruebas deviolencia y tres fosas individuales. En todos los casos se practicó la inhumación de los cadáveres, y se recuperaronindicios claros de enterramientos secundarios en alguna de sus formas posibles. Se presentan de forma individualizadalos resultados obtenidos de cada fosa, incluyendo información sobre los restos de cultura material hallados en el rellenojunto a la ofrecida por los estudios de antropología física, paleopatología, paleodieta, arqueopalinología y las cincodataciones de radiocarbono obtenidas de los restos humanos. Por último, se interpretan estos testimonios en el marcocultural de su época, insistiéndose en su consideración de enterramientos extraordinarios o de relegación, al margende la pauta funeraria normativa

Mitochondrial DNA in Osteoarthritis Disease

[Abstract] Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal joint function characterized by cartilage degradation, bone remodeling, osteophyte formation, and joint inflammation [1]. Recent insights into the epidemiology and impact of OA on patients have clearly established that OA is a severe disease of the whole joint as an organ, with large unmet medical needs. OA has a complex etiology that comprises the combination of multiple factors, including gender, age, occupation, trauma, body mass index, and genetics. Approximately, between 30 and 65% of the risk of OA is genetically determined [2] with evidence accumulated from different genome-wide association studies (GWAS) [3]. Most of these studies focused on nuclear genetic variants; however, over the last decade, evidence has accumulated for an association between specific mitochondrial DNA (mtDNA) genetic variants, called haplogroups, and different OA-related features, including prevalence, progression, and incidence [4].Instituto de Salud Carlos III; CIBERCB06/01/0040Instituto de Salud Carlos III; RETIC-RIER-RD16/0012/0002Instituto de Salud Carlos III; PRB2-ISCIII-PT17/0019/0014Instituto de Salud Carlos III; PI14/01254Instituto de Salud Carlos III; PI16/02124Instituto de Salud Carlos III; PI17/0021

Mitochondria and Mitophagy: Biosensors for Cartilage Degradation and Osteoarthritis

Editoria

Results on Argentine (Argentina spp.), Bluemouth (Helicolenus dactylopterus), Greater forkbeard (Phycis blennoides) and Spanish ling (Molva macrophthalma) from 2011 Porcupine Bank (NE Atlantic) survey

This paper presents the results on four of the mostimportant deep fish species of the last Porcupine Spanish survey carried in 2011, and updates the document presented in previous years with the information on the first ten years (2001-2010) of the PorcupineSpanish surveys. The document presents total abundances in weight, length frequencies and geographical distributions for Argentina spp. (mostly A. silus, results on A. silus/A. sphiraena distribution in last surveys are provided), bluemouth, greater fork-beard and Spanish ling. Also information on records of Blue ling during the survey series is shown.Versión de edito